Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine: by Erem Bilensoy

By Erem Bilensoy

Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine covers quite a lot of wisdom on cyclodextrins, from an outline of molecular and supramolecular elements of cyclodextrin physicochemistry, to the most recent results in cyclodextrin use and destiny percentages within the employment of those platforms. This publication makes a speciality of the derivatives and physicochemical and organic houses of cyclodextrins, and considers drug supply via topical, mucosal, and oral through cyclodextrin complexes.

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Pharm. , 24, 1–13. , Mura, P. (2006). Simultaneous effect of cyclodextrin complexation, pH, and hydrophilic polymers on naproxen solubilization. J. Pharm. Biomed. , 42, 126–131. , Schipper, N. (2004). Preparation of solid drug/cyclodextrin complexes of acidic and basic drugs. Pharmazie, 59, 25–29. B. (2007). Cyclodextrin multicomponent complexation and controlled release delivery strategies to optimize the oral bioavailability of vinpocetine. J. Pharm. , 96, 2018–2028. , Piel, G. (2007). Theoretical and experimental investigations on miconazole/cyclodextrin/acid complexes: molecular modeling studies.

But the increase in solubility remains predominant. Watersoluble polymers can increase the complexation efficiency by an increase in the stability constant [21]. 5. Influence of the Reaction Medium An inclusion complex between a guest and a CD can be obtained when both entities are in a molecular state. Thus, the complexation efficiency depends on the guest intrinsic solubility (S0) and the complex affinity constant (K): The method used to prepare an inclusion complex between a CD and a guest compound has a significant influence on the final product: yield, solubility, and stability of the complex.

Biomed. , 50, 683–689. 40. , Pinzauti, S. (1999). Influence of the preparation method on the physicochemical properties of ketoprofen–cyclodextrin binary systems. Int. J. , 179, 117–128. 41. , Ueda, H. (1994). The effect of water-soluble polymers on drug– cyclodextrin complexation. Int. J. , 110, 169–177. 42. , Mura, P. (2001). Effect of water-soluble polymers on naproxen complexation with natural and chemically modified b-cyclodextrins. Drug Dev. Ind. , 27, 909–917. 43. , Valsami, G. (2008). Effect of pH and water-soluble polymers on the aqueous solubility of nimesulide in the absence and presence of b-cyclodextrin derivatives.

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