Chromatin by Kensal E. van Holde (auth.)

By Kensal E. van Holde (auth.)

Contemporary perspectives at the constitution and serve as of chromatin are awarded and the background of the advance of those principles in addition to the character of the nucleic acid and protein parts of chromatin are reviewed. The constitution of chromatin is studied at a number of degrees, and its modes of transcription and replication are analyzed. Chromatin presents researchers with a severe review of present wisdom. It combines a lot info that hasn't ever prior to been assembled, and evaluates and interrelates it in a severe method. This has no longer been performed ahead of in order that readers aren't in simple terms supplied with an outline, yet with broad references to the literature (there are approximately 2000 references in all).

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R, . • ... olltr····... ................... 20 o 10 20 • 30 • o 40 % DIGESTION Fig. 2-4. Nucleosome oligomer sizes during micrococcal nuclease digestion of chromatin. The decrease in DNA fragment size during digestion results from exonucleitic attack on the DNA. ), and yeast (0). The sizes shown here are about 10% low, due to incorrect size calibration. From Lohr et al. (1977). (1976) studied a number of vertebrate and invertebrate cell types, with results demonstrating unequivocably that the repeat length varied over a wide range of values.

Olltr····... ................... 20 o 10 20 • 30 • o 40 % DIGESTION Fig. 2-4. Nucleosome oligomer sizes during micrococcal nuclease digestion of chromatin. The decrease in DNA fragment size during digestion results from exonucleitic attack on the DNA. ), and yeast (0). The sizes shown here are about 10% low, due to incorrect size calibration. From Lohr et al. (1977). (1976) studied a number of vertebrate and invertebrate cell types, with results demonstrating unequivocably that the repeat length varied over a wide range of values.

38 3. The Structures of DNA GROll Fig. 3-5. Angular parameters of twist (t), tilt (8,), and roll (8 R ) for a 2-strand poly- nucleotide helix. From Fratini et al. (1982), Journal of Biological Chemistry. they allow a clearer visualization of the structure. One is the axial translation per residue (the "rise," h) defined as the distance between equivalent points on successive residues projected onto the helix axis. The other parameters are the angles t, 8 T , and 8 R shown in Figure 3-5. " In a uniform helix, this will be related to the number of residues per turn, n (which may be integral or nonintegral), by n = 3600 /t.

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