Chemistry of Heterocyclic Compounds: Thiophene and its by Salo Gronowitz

By Salo Gronowitz

Content material:
Chapter I coaching of Thiophenes by means of Ring?Closure Reactions and from different Ring platforms (pages 1–214): Salo Gronowitz
Chapter II Theoretical Calculations on Thiophenes (pages 215–260): Anita Henriksson?Enflo
Chapter III evidently Occuring Thiophenes (pages 261–324): F. Bohlmann and C. Zdero
Chapter IV Thiophenes happening in Petroleum, Shale Oil, and Coals (pages 325–352): G. D. Galpern
Chapter V Pharmacologically lively Compounds and different Thiophene Derivatives (pages 353–456): Jeffery B. Press
Chapter VI relief and Desulfurization of Thiophene Compounds (pages 457–570): L. I. Belen'Kii and Y. A. L. Gol'Dfarb
Chapter VII Thiophene 1,1?Dioxides, Sesquioxides, and 1?Oxides (pages 571–628): Maynard S. Raasch
Chapter VIII response at Sulphur (pages 629–650): A. E. A. Porter
Chapter IX Radical Reactions of Thiophene (pages 651–670): A. E. A. Porter
Chapter X Cycloaddition Reactions of Thiophenes, Thiophene 1?Oxides, and 1,1?Dioxides (pages 671–744): P. H. Benders, D. N. Reinhoudt and W. P. Trompenaars
Chapter XI Photochemical Reactions of Thiophenes (pages 745–770): Alain Lablache?Combier

Show description

Read Online or Download Chemistry of Heterocyclic Compounds: Thiophene and its Derivatives, Part One, Volume 44 PDF

Best organic books

Contemporary Carbene Chemistry

Offers the main cutting edge leads to carbene chemistry, surroundings the root for brand spanking new discoveries and functions the invention of good carbenes has reinvigorated carbene chemistry learn, with investigators trying to boost carbenes into new important catalysts and ligands. offering the main leading edge and promising parts of carbene study over the last decade, this booklet explores newly came across structural, catalytic, and organometallic features of carbene chemistry, with an emphasis on new and rising man made purposes.

Catalyzed Carbon-Heteroatom Bond Formation

Written by way of an skilled editor commonly acclaimed in the medical neighborhood, this e-book covers every little thing from oxygen to nitrogen functionalities. From the contents: Palladium-Catalyzed Syntheses of 5-membered Saturated Heterocycles The Formation of Carbon-Sulfur and Carbon-Selenium Bonds via Substitution and Addition Reactions Catalyzed through Transition steel Complexes Palladium-Catalysis for Oxidative 1,2-Difunctionalization of Alkenes Palladium-Catalyzed Formation of fragrant Heterocycles Rhodium-Catalyzed Amination of C-H-Bonds Transition Metal-Catalyzed Synthesis of Heterocycles Copper-Catalyzed Synthesis of Azoles Palladium(II)-Catalyzed C-N Bond Formation related to Aminopalladation of Aklenes Carbon-Heteroatom Bond Formation via Rh(I)-Catalyzed Ring-Opening Reactions fresh Advances in Homogeneous Gold Catalysis: Formation of Carbon-Heteroatom Bonds the result's an necessary resource of knowledge for the strategic making plans of the unreal routes for natural, catalytic and medicinal chemists, in addition to chemists in undefined.

Named Organic Reactions, 2nd Edition

This moment version includes consise info on 134 rigorously selected named natural reactions - the normal set of undergraduate and graduate man made natural chemistry classes. each one response is particular with truly drawn mechanisms, references from the first literature, and well-written debts protecting the mechanical facets of the reactions, and the main points of facet reactions and substrate barriers.

Organotitanium Reagents in Organic Synthesis

Titanium has been used to accomplish many forms of reactions in natural and inorganic chemistry. the current ebook is worried basically with a brand new improvement in titanium chemistry that's beneficial in natural synthesis. In 1979/80 it used to be found that the titanation of classical carbanions utilizing C1TiX results in species with decreased basicity and reactivity.

Additional info for Chemistry of Heterocyclic Compounds: Thiophene and its Derivatives, Part One, Volume 44

Example text

The a,b-unsaturated nitrile 147 is first prepared by a Knoevenagel-Cope condensation and then reacted with sulfur and amine. Examples of the two-step procedure are given in Table 19. NEO] [ - CH, CONHPh I(CH,),SCH, 1 (CH,), --[(CH2) ,N(CH,)CH, 1CH-(CH,), R2 R24Hz R,--CO + CN A cisltrans 5,7-Me, mixture. (70) Yield of Thiophene CN CN CN CN CN CN CN CN CN CN CN CN CN CN 45 44 86 goa 74 80b 64 43 17 18 60 68 79 63 50 5 CN S 42 70 61 86 62 t CN CN CN CN CN X CHzX I THE GEWALD REACTION - MODIFICATION 2 a Another structure for these compounds is given in the publication.

17' Both 2-13C-and 3-13Cenriched thiophenes have been prepared by this method from, appropriately, 13C-enriched sodium ~ u c c i n a t e . ' ~A~ detailed procedure for the synthesis of 3-methylthiophene in 52-60% yield from disodium methylsuccinate, using mineral oil as diluent, has also been p~blished,'~'and 3-ethylthiophene was similarly and 3-aobtained from disodium e t h y l s u ~ c i n a t e . '41 In connection with work on optically active (+)-S-3-sec. butylthiophene, the reaction of optically active sec.

Similarly, the furanothiophenophane 112 was prepared from 1 1 1203 (Scheme 47). Mixed sulfides, such as 113, have also O + H Nc/ I - c // H\ 0 109 Yield (%) n 3 4 5 (CH30H) 6 (CH30H) 7 8 (CH30H) 10 110 9 36 3 4 (42) 44 ( 6 1 ) 61 58 (73) 91 (95) Scheme 46 111 112 Scheme 47 been used in the reaction with glyoxal, phenyl glyoxal, a-diketones, glyoxylates, mesaoxalates, and oxalates to give di- and trisubstituted thiophenes. '~~-~~~~'~~ metrical a-dicarbonyl compounds leads regiospecifically to only one isomer.

Download PDF sample

Rated 4.20 of 5 – based on 41 votes