Chemical Genomics and Proteomics by Ferenc Darvas, András Guttman, György Dormán

By Ferenc Darvas, András Guttman, György Dormán

Since the e-book of the pioneering first variation of Chemical Genomics and Proteomics greater than seven years in the past, the world of chemical genomics has quickly improved and varied to various novel equipment and subdisciplines, corresponding to chemical glycomics and lipidomics. This moment variation has been up to date to uniquely replicate this interdisciplinary function in addition to the extraordinary advancements that experience happened. the hot version additionally covers cutting edge functions from telephone biology to drug discovery to, extra lately, medical diagnostics and clinical perform, which make the most of the innovations of chemical genomics.

The textual content offers an summary of the innovations and methodologies of chemical genomics, concentrating on rising applied sciences and up to date purposes within the parts of blend chemical genetics, toxicogenomics, drug chemical genomics and proteomics, and orthogonal chemical genetics. It describes the advance and alertness of novel analytical equipment utilized in lipodomics, similar to steroidomics. The publication additionally discusses biomarker discovery functions of microarray applied sciences utilizing DNA, RNA, and protein and glycan arrays. Chapters disguise additional purposes of biomolecular biomarkers for ailment prognosis, in small molecule drug R&D, and through healing use of medications. those comprise prognostic, illness particular, reaction (surrogate), and toxicity biomarkers.

In addition, the textual content explores the foundations of latest platforms biology and genomics in experimental medicine―a new paradigm that demonstrates a network-oriented view and complicated statistical and informatics information administration, commencing the way in which towards custom-made drugs. eventually, a number of in silico chemogenomics methods are addressed for predicting binding of drug applicants to bad goals, which might assist in designing larger scientific applicants with fewer unintended effects. This re-creation advantages a huge variety of readers from commercial and educational researchers in drug discovery, medicinal chemistry, and molecular and phone biology to physicians in medical diagnostics and scholars in comparable fields of study.

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Chemical Genomics and Proteomics

Because the book of the pioneering first version of Chemical Genomics and Proteomics greater than seven years in the past, the realm of chemical genomics has speedily accelerated and assorted to various novel tools and subdisciplines, similar to chemical glycomics and lipidomics. This moment version has been up-to-date to uniquely replicate this interdisciplinary characteristic in addition to the impressive advancements that experience happened.

Extra info for Chemical Genomics and Proteomics

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Insights for the development of specific kinase inhibitors by targeted structural genomics. Drug Discov. Today 12(9–10):365–72. Frank, R. 2002. The SPOT-synthesis technique: Synthetic peptide arrays on membrane supports—Principles and applications. J. Immunol. Methods 267:13–26. Freundlieb, S. and Gamer, J. 2002. Chemical microarrays: A novel approach to drug discovery. New Drugs 3:54–60. , and Dibó, G. 1991. General method for rapid synthesis of multicomponent peptide mixtures. Int. J. Pept. Prot.

Such genotype-selective compounds either target oncoproteins directly or other critical proteins involved in the oncoprotein-linked signaling network. The major advantage of genotype-selective antitumor agents is that they are active primarily in the presence of specific genetic elements. Such a method is also useful for dissecting the oncogenic signaling network and tailoring chemotherapy to specific mutated tumor types. In order to characterize the lethality of the small molecules in tumorigenic cells, the compounds were also screened for cell viability against isogenic primary cells as a reference cell line.

Interestingly, verapamil (a class IV antiarrhythmic agent, an L-Type Ca2+ channel blocker) was identified exhibiting a striking procardiomyogenic effect. , 2009) Approximately 15% of all acute myeloid leukemia (AML) cases possess t(8;21) chromosome translocation that gives rise to the AML1/ETO fusion oncoprotein. AML1/ETO consists of the N-terminal DNA-binding domain of AML1, a transcription factor essential for definitive hematopoiesis, and almost all of ETO, a protein thought to function as a corepressor for a variety of transcription factors.

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