Chaperones (Topics in Current Genetics) by Marja Makarow, Ineke Braakman

By Marja Makarow, Ineke Braakman

Molecular chaperones have interaction with nearly each newly synthesized protein. This quantity assembles a set of experiences on molecular chaperones that's either well timed and uncomplicated. The publication uniquely combines the fundamentals of the topic sector with the most recent effects. This makes it a superb front for beginners into the sector and is appropriate for educating reasons. It additionally presents a resource of considerable info for specialists.

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Int J Dev Biol 44:471-477 Fargnoli J, Kunisada T, Fornace AJ Jr, Schneider EL, Holbrook NJ (1990) Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats. Proc Natl Acad Sci USA 87:846-850 Fawcett TW, Sylvester SL, Sarge KD, Morimoto RI, Holbrook NJ (1994) Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1. J Biol Chem 269:32272-32278 Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing.

J Biol Chem 278:35465-35475 Hietakangas V, Ahlskog JK, Jakobsson AM, Hellesuo M, Sahlberg NM, Holmberg CI, Mikhailov A, Palvimo JJ, Pirkkala L, Sistonen L (2003) Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Mol Cell Biol 23:2953-2968 Holmberg CI, Leppä S, Eriksson JE, Sistonen L (1997) The phorbol ester 12-Otetradecanoylphorbol 13-acetate enhances the heat-induced stress response. J Biol Chem 272:6792-6798 Holmberg CI, Illman SA, Kallio M, Mikhailov A, Sistonen L (2000) Formation of nuclear HSF1 granules varies depending on stress stimuli.

Under normal conditions (C), HSF1 is dispersed throughout the cell, mainly in the nucleus. Upon exposure to heat shock (HS), HSF1 translocates to the punctate nuclear stress bodies (nSBs). Immunofluorescence images of HSF1 localization in HeLa cells were obtained using monoclonal anti-HSF1 antibodies (Ab-4, NeoMarkers; images kindly provided by Anton Sandqvist). genes also apply to the transcription of satellite III repeats, and whether the localization of HSF1 to nSBs has any impact on the transcription of the classical heat shock genes.

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