Biophysics by Glaser

By Glaser

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This extraordinary agent is called a prion (proteinaceous infectious agent). 27 29 a 28 kD hydrophobic glycoprotein, PrP. PrP is coded by a cellular gene (conserved among the mammals) that is expressed in normal brain. The protein exists in two forms. The product found in normal brain is called PrPc. It is entirely degraded by proteases. The protein found in infected brains is called PrPsc. It is extremely resistant to degradation by proteases. PrPc is converted to PrPsc by a modification or conformational change that confers protease-resistance, and which has yet to be fully defined.

Nature 171, 964-967. Wilkins, M. F. , Stokes, A. , and Wilson, H. R. (1953). Molecular structure of DNA. Nature 171, 738-740. 7 DNA replication is semiconservative rev Holmes, F. (2001). Yale University Press. Meselson, Stahl, and the Replication of DNA: A History of The Most Beautiful Experiment in Biology, ref Meselson, M. and Stahl, F. W. (1958). The replication of DNA in E. coli. Proc. Nat. Acad. Sci. USA 44, 671-682. 10 Mutations change the sequence of DNA rev Drake, J. , and Balz, R. H. (1976).

MacMillan, London. DNA is the genetic material of bacteria Avery, 0. , MacLeod, C. , and McCarty, M. (1944). Studies on the chemical nature of the substance inducing transformation of pneumococcal types. J. Exp. Med. 98, 451-460. Griffith, F. (1928). The significance of pneumococcal types. J. Hyg. 27, 113-159. DNA is the genetic material of viruses Hershey, A. , and Chase, M. (1952). Independent functions of viral protein and nucleic acid in growth of bacteriophage. J. Gen. Physiol. 36, 39-56. , and Silverstein, S.

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