Biology of Negative Strand RNA Viruses: The Power of Reverse by K. K. Conzelmann (auth.), Professor Yoshihiro Kawaoka DVM,

By K. K. Conzelmann (auth.), Professor Yoshihiro Kawaoka DVM, PhD (eds.)

Negative-strand RNA viruses, so named as a result of polarity in their genomic RNA to mRNA, comprise vital human and non-human pathogens. opposite genetics, a method that permits iteration of recombinant viruses, was once first constructed for negative-strand RNA viruses in 1989. considering that then, it has sped up the speed of analysis on those viruses, resulting in a wealth of recent wisdom that another way could were tough to procure. extraordinary achievements that may be attributed to opposite genetics comprise the creation of inactivated and reside vaccine applicants and of vaccine and gene move vectors.

This quantity covers significant advances in opposite genetics suggestions during the last decade, cutting-edge easy technological know-how and the scientific implications of experimental findings. this could re-light curiosity in negative-strand RNA viruses between readers, together with these in different disciplines, resulting in additional development in figuring out those very important viruses and in constructing powerful measures of keep watch over.

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Virology 251:206-214 Johnson JE, Schnell MJ, Buonocore L, Rose JK (1997) Specific targeting to CD4+ cells of recombinant vesicular stomatitis viruses encoding human immunodeficiency virus envelope proteins. J Virol71:5060-5068 Johnson MC, Simon BE, Kim CH, Leong JA (2000) Production of recombinant snakehead rhabdovirus: the NV protein is not required for viral replication. J Virol 74:2343-2350 Kaelin K, Spielhofer P, Schneider H, Radecke F, Kunz C, Sidhu MS, Dowling PC, Udem SA, Billeter MA. Requirements for artificial measles virus mini- and midireplicons.

1995) and in the other by the vv late promoter P11 (Wyatt et al. 1995). MVA-T7 has been used immediately for recovery of the first Pneumovirus, RSV (Collins et al. 1995), the first Rubulavirus, SV5 (He et al. 1997), HPIV-3 (Durbin et al. 1997), rinderpest virus (Baron and Barrett 1997), and measles virus (Schneider et al. 1997). Other virus species followed, including "first" rescues of mumps virus (Clarke et al. 2000), CDV (Gassen et al. 2000), HPIV-2 (Kawano et al. 2001}, and BPIV-3 (Schmidt et al.

Virology 247:1-6 Roberts A, Rose JK (1999) Redesign and genetic dissection of the rhabdoviruses. Adv Virus Res 53:301-319 Romer-Oberdorfer A, Mundt E, Mebatsion T, Buchholz UJ, Mettenleiter TC (1999) Generation of recombinant lentogenic Newcastle disease virus from eDNA. J Gen Virol80 (Pt 11):2987-2995 Samal SK, Collins PL (1996) RNA replication by a respiratory syncytial virus RNA analog does not obey the rule of six and retains a nonviral trinucleotide extension at the leader end. J Virol 70:5075-5082 Schlender J, Bossert B, Buchholz U, Conzelmann KK (2000) Bovine respiratory syncytial virus nonstructural proteins NS1 and NS2 cooperatively antagonize alpha/ beta interferon-induced antiviral response.

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