Bioinformatics: A Practical Guide to the Analysis of Genes by Andreas D. Baxevanis, B. F. Francis Ouellette

By Andreas D. Baxevanis, B. F. Francis Ouellette

"In this e-book, Andy Baxevanis and Francis Ouellette . . . have undertaken the tricky activity of organizing the information during this box in a logical development and offering it in a digestible shape. they usually have performed an exceptional activity. This fantastic textual content will make an immense effect on organic study and, in flip, on growth in biomedicine. we're all of their debt."
—Eric Lander from the Foreword
Reviews from the 1st Edition
"...provides a extensive evaluate of the elemental instruments for series research ... For biologists imminent this topic for the 1st time, it will likely be a really important instruction manual to maintain at the shelf after the 1st examining, on the subject of the computer."
Nature Structural Biology
"...should be within the own library of any biologist who makes use of the net for the research of DNA and protein series data."
"...a excellent primer designed to navigate the amateur in the course of the intricacies of in scripto research ... The entire gene searcher also will locate this booklet an invaluable addition to their library ... a superb connection with the rules of bioinformatics."
Trends in Biochemical Sciences
This new version of the hugely profitable Bioinformatics: a pragmatic advisor to the research of Genes and Proteins presents a valid origin of simple strategies, with functional discussions and comparisons of either computational instruments and databases proper to organic research.
Equipping biologists with the fashionable instruments essential to clear up functional difficulties in series information research, the second one version covers the vast spectrum of issues in bioinformatics, starting from web options to predictive algorithms used on series, constitution, and expression facts. With chapters written by way of specialists within the box, this up to date reference completely covers very important options and is acceptable for either the amateur and the skilled practitioner. Written in transparent, uncomplicated language, the ebook is obtainable to clients with no a complicated mathematical or computing device technological know-how history. This new version includes:* All new end-of-chapter internet assets, bibliographies, and challenge units* Accompanying website containing the solutions to the issues, in addition to hyperlinks to correct net assets* New insurance of comparative genomics, large-scale genome research, series meeting, and expressed series tags* A thesaurus of regular phrases in bioinformatics and genomics
Bioinformatics: a realistic advisor to the research of Genes and Proteins, moment variation is key studying for researchers, teachers, and scholars of all degrees in molecular biology and bioinformatics, in addition to for investigators interested by genomics, positional cloning, medical learn, and computational biology.

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Extra resources for Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins (2nd Edition)

Sample text

This is because the accession identifies the whole database record. If the sequence in a record was updated (say by the insertion of 1000 bp at the beginning), the accession number did not change, as it was an updated version of the same record. If one had analyzed the original sequence and recorded that at position 100 of accession U00001 there was a putative protein-binding site, after the update a completely different sequence would be found at position 100! The accession number appears on the ACCESSION line of the GenBank record.

What to Define? 1. (A) Selected parts of GenBank-formatted records in a segmented sequence. GenBank format historically indicates merely that records are part of some ordered series; it offers no information on what the other components are or how they are connected. uid=6849043&form=6&db=n&Dopt=g. (B) Representation of segmented sequences in the new CON (contig) division. A new extension of GenBank format allows the details of the construction of segmented records to be presented. The CONTIG line can include individual accessions, gaps of known length, and gaps of unknown length.

The NCBI data model allows for both scenarios. At the time of this writing only the first form is supported in either MEDLINE or GenBank, both types may appear in published articles. Articles The most commonly cited bibliographic entity in biological science is an article in a journal; therefore, the citation formats of most biological databases are defined with that type in mind. However, ‘‘articles’’ can also appear in books, manuscripts, theses, and now in electronic journals as well. The data model defines the fields necessary to cite a book, a journal, or a manuscript.

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