Biochemistry and Genetics Flash Cards by Suzanne Baron

By Suzanne Baron

Clinical circumstances supply entire, concise insurance of the biochemical and genetic illnesses proven at the USMLE Step 1 and in simple technology courses.

  • A powerful specialize in the medical facets of biochemical and genetic affliction
  • Emphasizes boardrelevant assurance
  • Easily evaluate and distinction illnesses
  • Each disease-specific card incorporates a medical vignette
  • Important sickness proof are highlighted for speedy review

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Extra resources for Biochemistry and Genetics Flash Cards

Example text

The most salient features of each disease are highlighted in bold for ease of rapid review. We suggest using these cards as an adjunct to your biochemistry and genetics courses in medical school. Being familiar with these cards early on will be very helpful during your Step 1 review. We also encourage you to jot down your own notes in the margins and to make these cards your personal biochemistry and genetics review for the boards. We are confident that the newly revised second edition of Lange FlashCards: Biochemistry and Genetics will be one of the most powerful tools to help prepare you for the boards and will serve as a resource that will bridge your basic science knowledge with the clinical aspects of disease.

Substrates: Acetyl CoA; acetoacetyl CoA. 舦 Products: Cholesterol: Oxidized to bile acids in liver; precursor for steroid hormones. Mevalonic acid: Precursor for terpenes (eg, vitamins A and K, coenzyme Q). 舦 Regulation: HMG CoA reductase is inhibited by high levels of cholesterol. This enzyme is the pharmacologic target of lovastatin and other drugs in that class. 舦 Circulation: Two-thirds of plasma cholesterol is esterified by LCAT, an enzyme activated by apo A. Cholesterol esterification by LCAT traps cholesterol in HDL and prevents membrane cholesterol uptake, which can lead to alterations in membrane permeability.

She eats a regular diet and exercises twice a week. On physical examination, you notice cholesterol deposits in the palmar creases of both her hands. She also has two very small tuberous xanthomas near her buttocks. You believe that this patient suffers from an autosomal recessive disease and you order serum lipid studies, expecting to find elevated VLDL and IDL levels in the presence of normal LDL and HDL levels. You believe that the patient may benefit from niacin and clofibrate treatment. Dysbetalipoproteinemia Š A 52-year-old man presents to your primary care office for establishment of care.

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