Azolides in Organic Synthesis and Biochemistry by Heinz A. Staab, H. Bauer, K. M. Schneider
By Heinz A. Staab, H. Bauer, K. M. Schneider
Within the past due fifties and early sixties H. A. Staab stumbled on N,N'-carbonyl-diimidazole (CDI), its analogues, and the family members of azolides derived from them. quickly those compounds turned broadly liked as artificial development blocks of unsurpassed variety. The spectrum of drugs, that may be received through light acylation with azolides contains esters, amides, ketones, aldehydes, in addition to heterocycles, peptides, glycosides, and nucleotides.
Now, H. A. Staab, the 'father' of those helpful compounds, along with his coauthors H. Bauer and okay. M. Schneider, has collected their training, houses, and manifold functions in a finished and topical overview.
Are you within the box of synthesis of typical items, biomolecules, heterocycles, or different advanced natural compounds? Then, your first look may well good be into 'Staab'- this instruction manual must always be within sight of your table or lab bench.
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Additional info for Azolides in Organic Synthesis and Biochemistry
48] References  H. A. Staab, Chem. Ber. 1956, 89, 1927-1940; 2088-2093; 1957, 90, 1326-1330.  Reviews: H. A. Staab, Angew. Chem. 1962, 74,407-423; Angew. Chem. Int. Ed. Engl. 1962,1, 351367; H. A. Staab, W. Rohr, Neuere Methoden der Preparativen Organischen Chemie 1967, V, 5393; Newer Methods of Preparative Organic Chemistry 1967, V, 61—108. However, these reviews cover only the literature until the mid-60s.  L. Birkofer, P. Richter, A. Ritter, Chem. Ber. 1960, 93, 2804-2809.  G. S.
Esters prepared with ImCOCOIm. RC02X RCO2CH3 Yield (%) linoleic acid lithium linoleate sodium linoleate linolenic acid arachidonic acid methyl linoleate methyl linoleate methyl linoleate methyl linoleate methyl arachidonate 79 72 85 78 72 Further examples are mentioned in the reference  A base-catalyzed (terf-C4H9OK) reaction of MAT'-oxalyldiimidazole, prepared in situ from oxalyldichloride and imidazole, to give methyl linoleate (93%) is described in reference . 1 Syntheses of Carboxylic Esters 41 In the case of 2-(2-hydroxyethyl)piperidine it is not necessary to protect the NH group because of steric hindrance at this position.
7] H. A. Staab, Angew. Chem. 1959, 74, 164 (H. A. Staab, GDCh-Lecture Dec. 18, 1958).  G. W. Anderson, R. Paul, J. Amer. Chem. Soc. ); R. Paul, G. W. Anderson, ibid. 1960, 82, 4596-4600.  H. A. Staab, G. Maleck, Chem. Ber. 1966, 99, 2955-2961.  H. A. Staab, G. Walther, Liebigs Ann. Chem. 1962, 657, 98-103.  H. A. Staab, G. Walther, Chem. Ber. 1962, 95, 2070-2072.  H. A. Staab, M. Liiking, F. H. Durr, Chem. Ber. 1962, 95, 1275-1284.  H. A. Staab, D. Lauer, Chem. Ber. 1968, 101, 864-878.