Azolides in Organic Synthesis and Biochemistry by Heinz A. Staab, H. Bauer, K. M. Schneider

By Heinz A. Staab, H. Bauer, K. M. Schneider

Within the past due fifties and early sixties H. A. Staab stumbled on N,N'-carbonyl-diimidazole (CDI), its analogues, and the family members of azolides derived from them. quickly those compounds turned broadly liked as artificial development blocks of unsurpassed variety. The spectrum of drugs, that may be received through light acylation with azolides contains esters, amides, ketones, aldehydes, in addition to heterocycles, peptides, glycosides, and nucleotides.

Now, H. A. Staab, the 'father' of those helpful compounds, along with his coauthors H. Bauer and okay. M. Schneider, has collected their training, houses, and manifold functions in a finished and topical overview.

Are you within the box of synthesis of typical items, biomolecules, heterocycles, or different advanced natural compounds? Then, your first look may well good be into 'Staab'- this instruction manual must always be within sight of your table or lab bench.

Show description

Read or Download Azolides in Organic Synthesis and Biochemistry PDF

Similar organic books

Contemporary Carbene Chemistry

Provides the main cutting edge ends up in carbene chemistry, surroundings the basis for brand new discoveries and functions the invention of solid carbenes has reinvigorated carbene chemistry learn, with investigators looking to strengthen carbenes into new precious catalysts and ligands. providing the main cutting edge and promising components of carbene study over the last decade, this publication explores newly came upon structural, catalytic, and organometallic elements of carbene chemistry, with an emphasis on new and rising artificial functions.

Catalyzed Carbon-Heteroatom Bond Formation

Written through an skilled editor commonly acclaimed in the medical neighborhood, this e-book covers every little thing from oxygen to nitrogen functionalities. From the contents: Palladium-Catalyzed Syntheses of 5-membered Saturated Heterocycles The Formation of Carbon-Sulfur and Carbon-Selenium Bonds via Substitution and Addition Reactions Catalyzed by way of Transition steel Complexes Palladium-Catalysis for Oxidative 1,2-Difunctionalization of Alkenes Palladium-Catalyzed Formation of fragrant Heterocycles Rhodium-Catalyzed Amination of C-H-Bonds Transition Metal-Catalyzed Synthesis of Heterocycles Copper-Catalyzed Synthesis of Azoles Palladium(II)-Catalyzed C-N Bond Formation regarding Aminopalladation of Aklenes Carbon-Heteroatom Bond Formation by means of Rh(I)-Catalyzed Ring-Opening Reactions fresh Advances in Homogeneous Gold Catalysis: Formation of Carbon-Heteroatom Bonds the result's an quintessential resource of data for the strategic making plans of the factitious routes for natural, catalytic and medicinal chemists, in addition to chemists in undefined.

Named Organic Reactions, 2nd Edition

This moment version comprises consise info on 134 rigorously selected named natural reactions - the traditional set of undergraduate and graduate man made natural chemistry classes. each one response is distinctive with truly drawn mechanisms, references from the first literature, and well-written bills overlaying the mechanical elements of the reactions, and the main points of facet reactions and substrate barriers.

Organotitanium Reagents in Organic Synthesis

Titanium has been used to accomplish many different types of reactions in natural and inorganic chemistry. the current booklet is worried basically with a brand new improvement in titanium chemistry that is invaluable in natural synthesis. In 1979/80 it was once chanced on that the titanation of classical carbanions utilizing C1TiX results in species with lowered basicity and reactivity.

Additional info for Azolides in Organic Synthesis and Biochemistry

Example text

48] References [1] H. A. Staab, Chem. Ber. 1956, 89, 1927-1940; 2088-2093; 1957, 90, 1326-1330. [2] Reviews: H. A. Staab, Angew. Chem. 1962, 74,407-423; Angew. Chem. Int. Ed. Engl. 1962,1, 351367; H. A. Staab, W. Rohr, Neuere Methoden der Preparativen Organischen Chemie 1967, V, 5393; Newer Methods of Preparative Organic Chemistry 1967, V, 61—108. However, these reviews cover only the literature until the mid-60s. [3] L. Birkofer, P. Richter, A. Ritter, Chem. Ber. 1960, 93, 2804-2809. [4] G. S.

Esters prepared with ImCOCOIm. RC02X RCO2CH3 Yield (%) linoleic acid lithium linoleate sodium linoleate linolenic acid arachidonic acid methyl linoleate methyl linoleate methyl linoleate methyl linoleate methyl arachidonate 79 72 85 78 72 Further examples are mentioned in the reference [110] A base-catalyzed (terf-C4H9OK) reaction of MAT'-oxalyldiimidazole, prepared in situ from oxalyldichloride and imidazole, to give methyl linoleate (93%) is described in reference [111]. 1 Syntheses of Carboxylic Esters 41 In the case of 2-(2-hydroxyethyl)piperidine it is not necessary to protect the NH group because of steric hindrance at this position.

7] H. A. Staab, Angew. Chem. 1959, 74, 164 (H. A. Staab, GDCh-Lecture Dec. 18, 1958). [8] G. W. Anderson, R. Paul, J. Amer. Chem. Soc. ); R. Paul, G. W. Anderson, ibid. 1960, 82, 4596-4600. [9] H. A. Staab, G. Maleck, Chem. Ber. 1966, 99, 2955-2961. [10] H. A. Staab, G. Walther, Liebigs Ann. Chem. 1962, 657, 98-103. [11] H. A. Staab, G. Walther, Chem. Ber. 1962, 95, 2070-2072. [12] H. A. Staab, M. Liiking, F. H. Durr, Chem. Ber. 1962, 95, 1275-1284. [13] H. A. Staab, D. Lauer, Chem. Ber. 1968, 101, 864-878.

Download PDF sample

Rated 4.16 of 5 – based on 48 votes