Autoimmune Disease: Pathogenesis, Genetics, Immunotherapy, by Duncan Dartrey Adams

By Duncan Dartrey Adams

This ebook describes how the Jerne-Burnet Forbidden Clone thought and the Adams-Knight H Gene thought, solved the pathogenesis and genetics of the autoimmune ailments exhibiting how particular immunotherapy and prophylaxis will be constructed. moreover, Ebringer's discovery of 2 microbial triggers of autoimmune illnesses is defined and the belief drawn that each one autoimmune illnesses have microbial triggers, so might be preventable through the discovering of the triggers and vaccination opposed to them.

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Extra info for Autoimmune Disease: Pathogenesis, Genetics, Immunotherapy, Prophylaxis and Principles for Organ Transplantation

Sample text

In some patients the force was the Devil, in others, ‘‘wireless waves,’’ in the early days of radio, then ‘‘atomic radiation,’’ after advent of the atomic bomb. It was apparent to Adams that this meant that schizophrenia is not caused by any emotional upset, but is due to an acquired defect of biochemical activity in some part of the brain. The extremely limited and consistent nature of the abnormality was most encouraging, indicating causation by an acquired, precise defect of function and so giving great hope for the possibility of developing cure or prevention.

43. Adams DD. Autoimmune mechanisms. In: Davies TF, editor. Autoimmune endocrine disease. New York: Wiley; 1983. p. 1–39. 44. Adams DD. Systemic lupus erythaematosus: a simple concept of the pathogenesis and its genetic basis. In: Dawkins RL, Christiansen FT, Zilko PJ, editors. Immunogenetics in rheumatology. Amsterdam: Excerpta Medica; 1982. p. 242–3. 45. Lindstrom J, Shelton D, Fujii Y. Myasthenia gravis. Adv Immunol. 1988;42:233–84. 46. Ebringer A, Rashid T, Wilson C. Rheumatoid arthritis, Proteus, anti-CCP antibodies and Karl Popper.

Rheumatoid arthritis (RA) and Proteus mirabilis [2]. Multiple studies over three decades have found high titres of antibodies against this bacterium in a total of 1,375 RA patients, but not in other diseases or healthy controls, in studies by independent groups in 15 different countries. There was no such elevation in antibodies against 27 other microbial agents. There is evidence that the upper urinary tract is the main source of Proteus infection in RA (Fig. 1). Ankylosing spondylitis (AS) and Klebsiella [3].

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