ADP-Ribosylation Reactions. Biology and Medicine by Osamu Hayaishi
By Osamu Hayaishi
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Extra resources for ADP-Ribosylation Reactions. Biology and Medicine
0; and (4) when the dephosphorylated compound was permethylated and subjected to mass spectrometry, it yielded a molecular ion peak at a mass-to-charge ratio (mle) of 659. Permethylation with C H I resulted in shift of the molecular ion peak to mle = 684, indicating the presence of 9 methyl groups. The presence of these molecular ions showed that the molecular weight of the dephosphorylated compound was 531. Thus one mole of the compound contained one mole of adenine, three moles of ribose and three moles of phosphate.
Physicochemical Properties B. Biological Properties Conclusion References 43 43 47 49 56 56 59 62 62 I. STRUCTURE OF POLY(ADP-RIBOSE) A. , 1980). When poly(ADP-ribose) was first discovered its structure was thought to be as shown in Fig. 1. Poly (ADP-ribose) is similar to poly(A) in that it has adenine, ribose, and phosphate, but it differs in that the molar ratio of ribose ADP-RIBOSYLATION REACTIONS Copyright © 1982 by Academic Press, Inc. All rights of reproduction in any form reserved. ISBN 0-12-333660-0 43 44 Takashi Sugimura and Masanao Miwa Ade I ....
1970). Fed. Proc, Fed. Am. Soc. Exp. Biol. 29, 344. 2. Pyridine Nucleotide Metabolism and ADP-Ribosylation 39 Dietrich, L. , and Muniz, O. (1972). Biochemistry 11, 1691-1695. Dietrich, L. , and Yero, I. L. (1971). Methods Enzy mol. 18B, 156-162. Dietrich, L. , Yero, I. , and Martinez, L. (1966). J. Biol. Chem. 241, 188-191. Dietrich, L. , Muniz, O . , and Powanda, M. (1968). J. Vitaminol. 14, 123-129. Durkacz, B. W . , Omidiji, O . , Gray, D. Α . , and Shall, S. (1980). Nature (London) 283, 593-596.