A Systems Biology Approach to Blood by Seth Joel Corey, Marek Kimmel, Joshua N. Leonard

By Seth Joel Corey, Marek Kimmel, Joshua N. Leonard

The blood method is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood includes circulating cells, mobile fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments consequence from a highly-ordered strategy, hematopoiesis. Definitive hematopoiesis happens within the bone marrow, the place pluripotential stem cells provide upward push to a number of lineages of hugely really expert cells. Highly-productive and constantly regenerative, hematopoiesis calls for a microenvironment of mesenchymal cells and blood vessels.

A platforms Biology method of Blood is split into 3 major sections: easy parts, physiological techniques, and medical functions. utilizing blood as a window, you'll research wellbeing and fitness and disorder via this precise instrument field with reactive organic fluids that mirrors the present hemodynamics of the vessel partitions and many of the blood cellphone kinds. Many blood ailments, infrequent and customary can and feature been exploited utilizing platforms biology techniques with profitable effects and consequently excellent versions for platforms drugs. extra importantly, hematopoiesis deals the best studied structures with perception into stem mobile biology, mobile interplay, improvement; linage programing and reprograming which are each day motivated by means of the main mature and understood regulatory networks.

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2012;10(2):218–29. 90. Ranga A, Lutolf MP. High-throughput approaches for the analysis of extrinsic regulators of stem cell fate. Curr Opin Cell Biol. 2012;24(2):236–44. 91. Kokkaliaris KD, Loeffler D, Schroeder T. Advances in tracking hematopoiesis at the single-cell level. Curr Opin Hematol. 2012;19(4):243–9. 92. Schroeder T. Long-term single-cell imaging of mammalian stem cells. Nat Methods. 2011;8(4 Suppl):30–5. 93. Scherf N, Franke K, Glauche I, Kurth I, Bornhauser M, Werner C, et al. On the symmetry of siblings: automated single-cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup.

Small cocultures of arbitrary composition can be cultured in individual capsules within an environment of tailored factor composition and biomechanical properties and analyzed at high throughput [85, 86]. Another technique to mention in this context is single-cell PCR that has the ability to unveil information on the heterogeneity of transcription states within cell populations or among many of the microfluidic cocultures [87]. Biomimetics/Artificial Niches After identification of relevant niche components, their mode of action can be identified by an isolated analysis of these components in an in vitro setting, where all other factors can be controlled.

Automation in the laboratory facilitates combinatorial composition of various presumable niche components [90]. Taken together, the advances in controlling an increasing number of niche components in vitro pave the way to constructing artificial niches as valuable experimental setups. Image Analysis and Single Cell Tracking (In Vitro) The screening of niche components in vitro is an essential tool for studying their contributions to the stem cell niche. The results arising from these high-throughput experiments will generate a huge amount of data that mainly consist of micrographs.

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