3-scroll immersi in G (1,4) by Alzati A.
By Alzati A.
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Additional info for 3-scroll immersi in G (1,4)
It is believed that the primary mode of action of the chromones is to prevent the release of the chemical mediators that cause allergic symptoms from sensitised mast cells. This is supported by its use in the treatment of systemic mastocytosis. Otherwise the principle treatments for allergic disease have not changed markedly in recent years. Adrenaline (epinephrine) administered by injection was an early treatment for the bronchoconstriction of asthma, which subsequently changed to isoproteronol (isoprenaline) and more recently to both short-acting bronchodilators salbutamol and terbutaline, and long-acting bronchodilators salmeterol and formoterol.
However, there are more sophisticated methods available, such as computerised equipment for the delivery of inhaled doses of solid particles in specific bronchial challenges . Assessment of the Response Many different techniques are also available. It is now accepted that the test should be stopped when an immediate response is observed with at least a 20% fall in FEV1 (PD20FEV1), a 25% fall in the maximum mid-expiratory flow rate, or a 35% increase in specific airway resistances [78, 80]. However, the most used is PD20FEV1 since FEV1 is the most reproducible lung function test .
Wheat gluten in particular has been suspected of causing false-positive (irritant) reactions . The diagnostic performance of this test with food allergens can be evaluated by comparing the results with double-blind, placebo-controlled food challenges (DBPCFC). There is a task force to study standardisation of the challenge procedures for delayed reactions . Instead, the problem with aeroallergens is that a ‘gold standard’ provocation test in atopic eczema does not exist . Negative and Positive Control Solutions Because of inter-patient variability in cutaneous reactivity, it is necessary to include negative and positive controls in every skin test study.